First evidence for the use of organosilver compounds in Pd-catalyzed coupling reactions; a mechanistic rationale for the Pd/Ag-catalyzed enyne synthesis?

Silver acetylides have been prepared and used in Pd-catalyzed coupling reactions. Enynes have thus been obtained in good yields. This work demonstrates that organosilver compounds could enter the Pd catalytic cycle; it also supports the role of silver acetylides as intermediates in the new Pd/Ag-catalyzed coupling reaction.

New and easy route to primary cyclopropylamines from nitriles.

Starting from readily available substrates, we have developed a new synthesis of primary cyclopropylamines. The reaction involves a cooperative Ti(II)- and Lewis acid-mediated coupling of alkanenitriles with Grignard reagents.

Multiple pulmonary chondromata. A rare cause of neonatal respiratory distress.

A neonate with respiratory distress due to a right pneumothorax is presented. After drainage of the pneumothorax, atelectasis of the entire right lung developed. Because the atelectasis persisted, bronchoscopy was performed. On bronchoscopy the carina and right main-stem bronchus could not be visualized. Thoracotomy showed that the right main-stem bronchus was obstructed by a space-occupying lesion that was originating from the right upper lobe. Therefore, a sleeve resection of the right upper lobe was performed, and the right main-stem bronchus was reconstructed. Microscopic examination of the resected right upper lobe showed multiple chondromata. The lesions were located both in the lung parenchyma immediately beneath the pleura and in the bronchial wall. Pulmonary chondromata are rarely diagnosed in children. To our knowledge, this is the youngest patient ever presented with pulmonary chondromata.

Theory and practice: bridging scientists' and practitioners' roles.

Past and recent progress in theory development for psychiatric mental health nursing (PMHN) and its link to practice are reviewed. Results of a national survey of practitioners reflecting the current use of theory from the disciplines of nursing, psychiatry, and behavioral sciences are reported. Progress addressed in furthering the science of PMHN includes the taxonomy of nursing diagnoses and concept analysis. Case study methods are acknowledged as one approach to continue theory development. One paradigm, representative case research (RCR), is noted for its heuristic value for theory development and its potential for bridging the scientist-practitioner roles of mental health clinicians.